General Information

  • ID:  hor001051
  • Uniprot ID:  NA
  • Protein name:  FIRFamide
  • Gene name:  NA
  • Organism:  Diploptera punctata
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SKPANFIRF
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulated juvenile hormone release but acted only on corpora allata from females at the end of vitellogenesis.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001051_AF2.pdbhor001051_ESM.pdb

Physical Information

Mass: 122213 Formula: C51H78N14O12
Absent amino acids: CDEGHLMQTVWY Common amino acids: F
pI: 11.65 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: -26.67 Boman Index: -1782
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 54.44
Instability Index: 521.11 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  14706529
  • Title:  Localization and physiological effects of RFamides in the corpora allata of the cockroach Diploptera punctata in relation to allatostatins